Much about HIV

Much ado about nothing?

I t all started with the submission of an unsolicited review on idiopathic pulmonary haemosiderosis by IOACHIMESCU et al. [1]. During the review process of this excellent manuscript, the idea evolved to launch a whole series on rare (orphan) interstitial lung disorders in the European Respiratory Journal. Why bother? Well, admittedly, these diseases are rare, but for the affected patient that d...

Doing Much About Nothing

One of the interesting problems concerning experimental results is what happens when an experiment gives a null result, when the phenomenon expected is not observed. Is it because the experimental apparatus and the associated analysis procedures cannot detect or measure the phenomenon in question or is it because the phenomenon is not present? This is a real problem in the practice of physics. ...

Much Ado about Nothing

Let us start with non-existent objects. I will assume a certain view of these. I will not defend it here; this has been done elsewhere.2 The point in what follows will be to apply it. So let me simply summarise the core points. Some objects do not exist: fictional characters, such as Sherlock Holmes; failed objects of scientific postulation, such as the mooted planet Vulcan; God (any one that y...

Much ado about nothing?

Much Ado about Nogo

Three proteins in mature myelin (Nogo, MAG, and OMgp) have been purported to be critical in causing both regenerative failure and minimal sprouting after CNS injury. However, the role of this repulsive trio in vivo has been controversial. Lee et al., in this issue of Neuron, provide evidence that genetically deleting all three major myelin inhibitors either singly or all together does not resul...